Revised histopathological consensus classification of joint implant related pathology.
Identifieur interne : 000340 ( Main/Exploration ); précédent : 000339; suivant : 000341Revised histopathological consensus classification of joint implant related pathology.
Auteurs : V. Krenn [Allemagne] ; L. Morawietz [Allemagne] ; G. Perino [États-Unis] ; H. Kienapfel [Allemagne] ; R. Ascherl [Allemagne] ; G J Hassenpflug [Allemagne] ; M. Thomsen [Allemagne] ; P. Thomas [Allemagne] ; M. Huber [Autriche] ; D. Kendoff [Allemagne] ; D. Baumhoer [Suisse] ; M G Krukemeyer [Allemagne] ; S. Natu [Royaume-Uni] ; F. Boettner [États-Unis] ; J. Zustin [Allemagne] ; B. Kölbel [Allemagne] ; W. Rüther [Allemagne] ; J P Kretzer [Allemagne] ; A. Tiemann [Allemagne] ; A. Trampuz [Allemagne] ; L. Frommelt [Allemagne] ; R. Tichilow [Russie] ; S. Söder [Allemagne] ; S. Müller [Allemagne] ; J. Parvizi [États-Unis] ; U. Illgner [Allemagne] ; T. Gehrke [Allemagne]Source :
- Pathology, research and practice [ 1618-0631 ] ; 2014.
English descriptors
- KwdEn :
- Arthroplasty, Replacement (adverse effects), Arthroplasty, Replacement (instrumentation), Biomarkers (analysis), Biopsy, Consensus, Humans, Immunohistochemistry, Joint Prosthesis (adverse effects), Joints (chemistry), Joints (pathology), Joints (surgery), Predictive Value of Tests, Prosthesis Design, Prosthesis Failure, Prosthesis-Related Infections (classification), Prosthesis-Related Infections (metabolism), Prosthesis-Related Infections (pathology), Terminology as Topic, Treatment Outcome.
- MESH :
- chemical , analysis : Biomarkers.
- adverse effects : Arthroplasty, Replacement, Joint Prosthesis.
- chemistry : Joints.
- classification : Prosthesis-Related Infections.
- instrumentation : Arthroplasty, Replacement.
- metabolism : Prosthesis-Related Infections.
- pathology : Joints, Prosthesis-Related Infections.
- surgery : Joints.
- Biopsy, Consensus, Humans, Immunohistochemistry, Predictive Value of Tests, Prosthesis Design, Prosthesis Failure, Terminology as Topic, Treatment Outcome.
Abstract
This extended classification of joint implant related pathology is a practical histopathologic classification based on defined morphological criteria covering the complete spectrum of pathohistologic changes in periprosthetic tissues. These changes may occur as a consequence of endoprosthetic replacement of large joints and may lead to a reduction in the prosthesis survival rate. We describe the established consensus classification of the periprosthetic membrane, in which aseptic and septic prosthetic loosening can be subdivided into four histological types, as well as histopathological criteria for additional significant pathologies including endoprosthetic-associated arthrofibrosis, particle-induced immunological, inflammatory and toxic mechanisms (adverse reactions), and bone tissue pathologies. These characteristic tissue alterations and their relationships are summarized in the extended classification. Since particle heterogeneity in periprosthetic tissue is high and particle identification is a necessary part of diagnosis, the identification of different types of particles is described in the histopathological particle algorithm. The morphological qualities of prosthetic material particles and the demarcation between abrasion and non-abrasion endogenous particles are also summarized. This feasible classification which is based on low cost standard tissue processing and examination and on well-defined diagnostic criteria is a solid platform for the histological diagnosis of implant associated pathologies providing a stable and reproducible tool for the surgical pathologist. Since this classification is suitable for standardized histopathological diagnostics, it might also provide a useful data set for joint arthroplasty registers, particularly for registers based on so-called routine data.
DOI: 10.1016/j.prp.2014.09.017
PubMed: 25454771
Affiliations:
- Allemagne, Autriche, Royaume-Uni, Russie, Suisse, États-Unis
- Basse-Saxe, Bavière, Berlin, Brandebourg, District de Haute-Bavière, District de Moyenne-Franconie, Hambourg, Pennsylvanie, Schleswig-Holstein, Vienne (Autriche), État de New York
- Berlin, Erlangen, Hambourg, Kiel, Munich, Osnabrück, Philadelphie, Potsdam, Vienne (Autriche)
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Le document en format XML
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Huber</name><affiliation wicri:level="3"><nlm:affiliation>Pathologisch-bakteriologisches Institut, Otto Wagner Spital, Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Pathologisch-bakteriologisches Institut, Otto Wagner Spital, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Kendoff, D" sort="Kendoff, D" uniqKey="Kendoff D" first="D" last="Kendoff">D. Kendoff</name><affiliation wicri:level="3"><nlm:affiliation>Helios Endo-Klinik, Hamburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Helios Endo-Klinik, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Baumhoer, D" sort="Baumhoer, D" uniqKey="Baumhoer D" first="D" last="Baumhoer">D. Baumhoer</name><affiliation wicri:level="1"><nlm:affiliation>Bone Tumor Reference Center at the Institut of Pathology, University Hospital Basel, Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Bone Tumor Reference Center at the Institut of Pathology, University Hospital Basel, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Krukemeyer, M G" sort="Krukemeyer, M G" uniqKey="Krukemeyer M" first="M G" last="Krukemeyer">M G Krukemeyer</name><affiliation wicri:level="3"><nlm:affiliation>Paracelsus-Kliniken Deutschland Gmbh, Osnabrück, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Paracelsus-Kliniken Deutschland Gmbh, Osnabrück</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Osnabrück</settlement></placeName></affiliation></author><author><name sortKey="Natu, S" sort="Natu, S" uniqKey="Natu S" first="S" last="Natu">S. Natu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, University hospital of North Tees and Hartlepool NHS Foundation Trust, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Pathology, University hospital of North Tees and Hartlepool NHS Foundation Trust</wicri:regionArea><wicri:noRegion>University hospital of North Tees and Hartlepool NHS Foundation Trust</wicri:noRegion></affiliation></author><author><name sortKey="Boettner, F" sort="Boettner, F" uniqKey="Boettner F" first="F" last="Boettner">F. Boettner</name><affiliation wicri:level="2"><nlm:affiliation>Adult Reconstruction and Joint Replacement Division, Hospital for Special Surgery, New York, NYC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Adult Reconstruction and Joint Replacement Division, Hospital for Special Surgery, New York, NYC</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Zustin, J" sort="Zustin, J" uniqKey="Zustin J" first="J" last="Zustin">J. Zustin</name><affiliation wicri:level="1"><nlm:affiliation>Gerhard Domagk Institute of Pathology, University of Münster, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Gerhard Domagk Institute of Pathology, University of Münster</wicri:regionArea><wicri:noRegion>University of Münster</wicri:noRegion><wicri:noRegion>University of Münster</wicri:noRegion><wicri:noRegion>University of Münster</wicri:noRegion></affiliation></author><author><name sortKey="Kolbel, B" sort="Kolbel, B" uniqKey="Kolbel B" first="B" last="Kölbel">B. Kölbel</name><affiliation wicri:level="1"><nlm:affiliation>MVZ-Zentrum für Histologie, Zytologie und Molekulare Diagnostik, Trier, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>MVZ-Zentrum für Histologie, Zytologie und Molekulare Diagnostik, Trier</wicri:regionArea><wicri:noRegion>Trier</wicri:noRegion><wicri:noRegion>Trier</wicri:noRegion><wicri:noRegion>Trier</wicri:noRegion></affiliation></author><author><name sortKey="Ruther, W" sort="Ruther, W" uniqKey="Ruther W" first="W" last="Rüther">W. Rüther</name><affiliation wicri:level="1"><nlm:affiliation>Universitätsklinikum Hamburg-Eppendorf Zentrum für Operative Medizin, Klinik für Orthopädie, Hamburg-Eppendorf, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Universitätsklinikum Hamburg-Eppendorf Zentrum für Operative Medizin, Klinik für Orthopädie, Hamburg-Eppendorf</wicri:regionArea><wicri:noRegion>Hamburg-Eppendorf</wicri:noRegion><wicri:noRegion>Hamburg-Eppendorf</wicri:noRegion><wicri:noRegion>Hamburg-Eppendorf</wicri:noRegion></affiliation></author><author><name sortKey="Kretzer, J P" sort="Kretzer, J P" uniqKey="Kretzer J" first="J P" last="Kretzer">J P Kretzer</name><affiliation wicri:level="1"><nlm:affiliation>Labor für Biomechanik und Implantatforschung, Klinik für Orthopädie und Unfallchirurgie, Universitätsklinikum Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Labor für Biomechanik und Implantatforschung, Klinik für Orthopädie und Unfallchirurgie, Universitätsklinikum Heidelberg</wicri:regionArea><wicri:noRegion>Universitätsklinikum Heidelberg</wicri:noRegion><wicri:noRegion>Universitätsklinikum Heidelberg</wicri:noRegion><wicri:noRegion>Universitätsklinikum Heidelberg</wicri:noRegion></affiliation></author><author><name sortKey="Tiemann, A" sort="Tiemann, A" uniqKey="Tiemann A" first="A" last="Tiemann">A. Tiemann</name><affiliation wicri:level="1"><nlm:affiliation>Klinik für Orthopädie und Unfallchirurgie, SRH Zentralklinikum Suhl, Suhl, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Klinik für Orthopädie und Unfallchirurgie, SRH Zentralklinikum Suhl, Suhl</wicri:regionArea><wicri:noRegion>Suhl</wicri:noRegion><wicri:noRegion>Suhl</wicri:noRegion><wicri:noRegion>Suhl</wicri:noRegion></affiliation></author><author><name sortKey="Trampuz, A" sort="Trampuz, A" uniqKey="Trampuz A" first="A" last="Trampuz">A. Trampuz</name><affiliation wicri:level="3"><nlm:affiliation>Klinik für Orthopädie, Center für Muskuloskeletale Chirurgie, Charité Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Klinik für Orthopädie, Center für Muskuloskeletale Chirurgie, Charité Universitätsmedizin Berlin, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Frommelt, L" sort="Frommelt, L" uniqKey="Frommelt L" first="L" last="Frommelt">L. Frommelt</name><affiliation wicri:level="1"><nlm:affiliation>Mikrobiologie und Infektionsepidemiologie in Hamburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Mikrobiologie und Infektionsepidemiologie in Hamburg</wicri:regionArea></affiliation></author><author><name sortKey="Tichilow, R" sort="Tichilow, R" uniqKey="Tichilow R" first="R" last="Tichilow">R. Tichilow</name><affiliation wicri:level="1"><nlm:affiliation>R.R. Vreden Russian Scientific Research Institute of Traumatology and Orthopedics, Saint Petersburg, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>R.R. Vreden Russian Scientific Research Institute of Traumatology and Orthopedics, Saint Petersburg</wicri:regionArea><wicri:noRegion>Saint Petersburg</wicri:noRegion></affiliation></author><author><name sortKey="Soder, S" sort="Soder, S" uniqKey="Soder S" first="S" last="Söder">S. Söder</name><affiliation wicri:level="3"><nlm:affiliation>Pathologisches Institut, Universitätsklinikum Erlangen, Erlangen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Pathologisches Institut, Universitätsklinikum Erlangen, Erlangen</wicri:regionArea><placeName><settlement type="city">Erlangen</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Moyenne-Franconie</region></placeName></affiliation></author><author><name sortKey="Muller, S" sort="Muller, S" uniqKey="Muller S" first="S" last="Müller">S. Müller</name><affiliation wicri:level="1"><nlm:affiliation>MVZ-Zentrum für Histologie, Zytologie und Molekulare Diagnostik, Trier, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>MVZ-Zentrum für Histologie, Zytologie und Molekulare Diagnostik, Trier</wicri:regionArea><wicri:noRegion>Trier</wicri:noRegion><wicri:noRegion>Trier</wicri:noRegion><wicri:noRegion>Trier</wicri:noRegion></affiliation></author><author><name sortKey="Parvizi, J" sort="Parvizi, J" uniqKey="Parvizi J" first="J" last="Parvizi">J. Parvizi</name><affiliation wicri:level="3"><nlm:affiliation>The Rothman Institute at Thomas Jefferson University, Sheridan Building, Philadelphia, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Rothman Institute at Thomas Jefferson University, Sheridan Building, Philadelphia</wicri:regionArea><placeName><settlement type="city">Philadelphie</settlement><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Illgner, U" sort="Illgner, U" uniqKey="Illgner U" first="U" last="Illgner">U. Illgner</name><affiliation wicri:level="1"><nlm:affiliation>St. Josef-Stift Sendenhorst, Klinik für Orthopädie, Unfall- und Handchirurgie, Sendenhorst, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>St. Josef-Stift Sendenhorst, Klinik für Orthopädie, Unfall- und Handchirurgie, Sendenhorst</wicri:regionArea><wicri:noRegion>Sendenhorst</wicri:noRegion><wicri:noRegion>Sendenhorst</wicri:noRegion><wicri:noRegion>Sendenhorst</wicri:noRegion></affiliation></author><author><name sortKey="Gehrke, T" sort="Gehrke, T" uniqKey="Gehrke T" first="T" last="Gehrke">T. Gehrke</name><affiliation wicri:level="3"><nlm:affiliation>Helios Endo-Klinik, Hamburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Helios Endo-Klinik, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:25454771</idno><idno type="pmid">25454771</idno><idno type="doi">10.1016/j.prp.2014.09.017</idno><idno type="wicri:Area/PubMed/Corpus">000309</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000309</idno><idno type="wicri:Area/PubMed/Curation">000309</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000309</idno><idno type="wicri:Area/PubMed/Checkpoint">000309</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000309</idno><idno type="wicri:Area/Ncbi/Merge">000744</idno><idno type="wicri:Area/Ncbi/Curation">000744</idno><idno type="wicri:Area/Ncbi/Checkpoint">000744</idno><idno type="wicri:Area/Main/Merge">000341</idno><idno type="wicri:Area/Main/Curation">000340</idno><idno type="wicri:Area/Main/Exploration">000340</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Revised histopathological consensus classification of joint implant related pathology.</title><author><name sortKey="Krenn, V" sort="Krenn, V" uniqKey="Krenn V" first="V" last="Krenn">V. Krenn</name><affiliation wicri:level="1"><nlm:affiliation>MVZ-Zentrum für Histologie, Zytologie und Molekulare Diagnostik, Trier, Germany. Electronic address: krenn@patho-trier.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>MVZ-Zentrum für Histologie, Zytologie und Molekulare Diagnostik, Trier</wicri:regionArea><wicri:noRegion>Trier</wicri:noRegion><wicri:noRegion>Trier</wicri:noRegion><wicri:noRegion>Trier</wicri:noRegion></affiliation></author><author><name sortKey="Morawietz, L" sort="Morawietz, L" uniqKey="Morawietz L" first="L" last="Morawietz">L. Morawietz</name><affiliation wicri:level="3"><nlm:affiliation>Diagnostik Ernst von Bergmann GmbH, Institute of Pathology, Potsdam, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Diagnostik Ernst von Bergmann GmbH, Institute of Pathology, Potsdam</wicri:regionArea><placeName><region type="land" nuts="2">Brandebourg</region><settlement type="city">Potsdam</settlement></placeName></affiliation></author><author><name sortKey="Perino, G" sort="Perino, G" uniqKey="Perino G" first="G" last="Perino">G. Perino</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology and Laboratory Medicine, Hospital for Special Surgery, New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, Hospital for Special Surgery, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Kienapfel, H" sort="Kienapfel, H" uniqKey="Kienapfel H" first="H" last="Kienapfel">H. Kienapfel</name><affiliation wicri:level="3"><nlm:affiliation>Klinik für Spez. Orthopädische Chirurgie und Unfallchirurgie, Auguste Viktoria Klinikum, Vivantes Netzwerk, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Klinik für Spez. Orthopädische Chirurgie und Unfallchirurgie, Auguste Viktoria Klinikum, Vivantes Netzwerk, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Ascherl, R" sort="Ascherl, R" uniqKey="Ascherl R" first="R" last="Ascherl">R. Ascherl</name><affiliation wicri:level="1"><nlm:affiliation>Zentrum für Spezial- und Wechselendoprothetik und chirurgische Infektiologie, Zeisigwaldkliniken Bethanien, Chemnitz, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Zentrum für Spezial- und Wechselendoprothetik und chirurgische Infektiologie, Zeisigwaldkliniken Bethanien, Chemnitz</wicri:regionArea><wicri:noRegion>Chemnitz</wicri:noRegion><wicri:noRegion>Chemnitz</wicri:noRegion><wicri:noRegion>Chemnitz</wicri:noRegion></affiliation></author><author><name sortKey="Hassenpflug, G J" sort="Hassenpflug, G J" uniqKey="Hassenpflug G" first="G J" last="Hassenpflug">G J Hassenpflug</name><affiliation wicri:level="3"><nlm:affiliation>Klinik für Orthopädie, Universitätsklinikum Schleswig-Holstein, Kiel, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Klinik für Orthopädie, Universitätsklinikum Schleswig-Holstein, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Thomsen, M" sort="Thomsen, M" uniqKey="Thomsen M" first="M" last="Thomsen">M. Thomsen</name><affiliation wicri:level="1"><nlm:affiliation>Klinik für Orthopädie, DRK Klinik, Baden-Baden, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Klinik für Orthopädie, DRK Klinik, Baden-Baden</wicri:regionArea><wicri:noRegion>Baden-Baden</wicri:noRegion><wicri:noRegion>Baden-Baden</wicri:noRegion><wicri:noRegion>Baden-Baden</wicri:noRegion></affiliation></author><author><name sortKey="Thomas, P" sort="Thomas, P" uniqKey="Thomas P" first="P" last="Thomas">P. Thomas</name><affiliation wicri:level="3"><nlm:affiliation>Klinik und Poliklinik für Dermatologie und Allergologie der LMU, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Klinik und Poliklinik für Dermatologie und Allergologie der LMU, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Huber, M" sort="Huber, M" uniqKey="Huber M" first="M" last="Huber">M. Huber</name><affiliation wicri:level="3"><nlm:affiliation>Pathologisch-bakteriologisches Institut, Otto Wagner Spital, Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Pathologisch-bakteriologisches Institut, Otto Wagner Spital, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Kendoff, D" sort="Kendoff, D" uniqKey="Kendoff D" first="D" last="Kendoff">D. Kendoff</name><affiliation wicri:level="3"><nlm:affiliation>Helios Endo-Klinik, Hamburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Helios Endo-Klinik, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Baumhoer, D" sort="Baumhoer, D" uniqKey="Baumhoer D" first="D" last="Baumhoer">D. Baumhoer</name><affiliation wicri:level="1"><nlm:affiliation>Bone Tumor Reference Center at the Institut of Pathology, University Hospital Basel, Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Bone Tumor Reference Center at the Institut of Pathology, University Hospital Basel, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Krukemeyer, M G" sort="Krukemeyer, M G" uniqKey="Krukemeyer M" first="M G" last="Krukemeyer">M G Krukemeyer</name><affiliation wicri:level="3"><nlm:affiliation>Paracelsus-Kliniken Deutschland Gmbh, Osnabrück, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Paracelsus-Kliniken Deutschland Gmbh, Osnabrück</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Osnabrück</settlement></placeName></affiliation></author><author><name sortKey="Natu, S" sort="Natu, S" uniqKey="Natu S" first="S" last="Natu">S. Natu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, University hospital of North Tees and Hartlepool NHS Foundation Trust, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Pathology, University hospital of North Tees and Hartlepool NHS Foundation Trust</wicri:regionArea><wicri:noRegion>University hospital of North Tees and Hartlepool NHS Foundation Trust</wicri:noRegion></affiliation></author><author><name sortKey="Boettner, F" sort="Boettner, F" uniqKey="Boettner F" first="F" last="Boettner">F. Boettner</name><affiliation wicri:level="2"><nlm:affiliation>Adult Reconstruction and Joint Replacement Division, Hospital for Special Surgery, New York, NYC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Adult Reconstruction and Joint Replacement Division, Hospital for Special Surgery, New York, NYC</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Zustin, J" sort="Zustin, J" uniqKey="Zustin J" first="J" last="Zustin">J. Zustin</name><affiliation wicri:level="1"><nlm:affiliation>Gerhard Domagk Institute of Pathology, University of Münster, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Gerhard Domagk Institute of Pathology, University of Münster</wicri:regionArea><wicri:noRegion>University of Münster</wicri:noRegion><wicri:noRegion>University of Münster</wicri:noRegion><wicri:noRegion>University of Münster</wicri:noRegion></affiliation></author><author><name sortKey="Kolbel, B" sort="Kolbel, B" uniqKey="Kolbel B" first="B" last="Kölbel">B. Kölbel</name><affiliation wicri:level="1"><nlm:affiliation>MVZ-Zentrum für Histologie, Zytologie und Molekulare Diagnostik, Trier, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>MVZ-Zentrum für Histologie, Zytologie und Molekulare Diagnostik, Trier</wicri:regionArea><wicri:noRegion>Trier</wicri:noRegion><wicri:noRegion>Trier</wicri:noRegion><wicri:noRegion>Trier</wicri:noRegion></affiliation></author><author><name sortKey="Ruther, W" sort="Ruther, W" uniqKey="Ruther W" first="W" last="Rüther">W. Rüther</name><affiliation wicri:level="1"><nlm:affiliation>Universitätsklinikum Hamburg-Eppendorf Zentrum für Operative Medizin, Klinik für Orthopädie, Hamburg-Eppendorf, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Universitätsklinikum Hamburg-Eppendorf Zentrum für Operative Medizin, Klinik für Orthopädie, Hamburg-Eppendorf</wicri:regionArea><wicri:noRegion>Hamburg-Eppendorf</wicri:noRegion><wicri:noRegion>Hamburg-Eppendorf</wicri:noRegion><wicri:noRegion>Hamburg-Eppendorf</wicri:noRegion></affiliation></author><author><name sortKey="Kretzer, J P" sort="Kretzer, J P" uniqKey="Kretzer J" first="J P" last="Kretzer">J P Kretzer</name><affiliation wicri:level="1"><nlm:affiliation>Labor für Biomechanik und Implantatforschung, Klinik für Orthopädie und Unfallchirurgie, Universitätsklinikum Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Labor für Biomechanik und Implantatforschung, Klinik für Orthopädie und Unfallchirurgie, Universitätsklinikum Heidelberg</wicri:regionArea><wicri:noRegion>Universitätsklinikum Heidelberg</wicri:noRegion><wicri:noRegion>Universitätsklinikum Heidelberg</wicri:noRegion><wicri:noRegion>Universitätsklinikum Heidelberg</wicri:noRegion></affiliation></author><author><name sortKey="Tiemann, A" sort="Tiemann, A" uniqKey="Tiemann A" first="A" last="Tiemann">A. Tiemann</name><affiliation wicri:level="1"><nlm:affiliation>Klinik für Orthopädie und Unfallchirurgie, SRH Zentralklinikum Suhl, Suhl, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Klinik für Orthopädie und Unfallchirurgie, SRH Zentralklinikum Suhl, Suhl</wicri:regionArea><wicri:noRegion>Suhl</wicri:noRegion><wicri:noRegion>Suhl</wicri:noRegion><wicri:noRegion>Suhl</wicri:noRegion></affiliation></author><author><name sortKey="Trampuz, A" sort="Trampuz, A" uniqKey="Trampuz A" first="A" last="Trampuz">A. Trampuz</name><affiliation wicri:level="3"><nlm:affiliation>Klinik für Orthopädie, Center für Muskuloskeletale Chirurgie, Charité Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Klinik für Orthopädie, Center für Muskuloskeletale Chirurgie, Charité Universitätsmedizin Berlin, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Frommelt, L" sort="Frommelt, L" uniqKey="Frommelt L" first="L" last="Frommelt">L. Frommelt</name><affiliation wicri:level="1"><nlm:affiliation>Mikrobiologie und Infektionsepidemiologie in Hamburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Mikrobiologie und Infektionsepidemiologie in Hamburg</wicri:regionArea></affiliation></author><author><name sortKey="Tichilow, R" sort="Tichilow, R" uniqKey="Tichilow R" first="R" last="Tichilow">R. Tichilow</name><affiliation wicri:level="1"><nlm:affiliation>R.R. Vreden Russian Scientific Research Institute of Traumatology and Orthopedics, Saint Petersburg, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>R.R. Vreden Russian Scientific Research Institute of Traumatology and Orthopedics, Saint Petersburg</wicri:regionArea><wicri:noRegion>Saint Petersburg</wicri:noRegion></affiliation></author><author><name sortKey="Soder, S" sort="Soder, S" uniqKey="Soder S" first="S" last="Söder">S. Söder</name><affiliation wicri:level="3"><nlm:affiliation>Pathologisches Institut, Universitätsklinikum Erlangen, Erlangen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Pathologisches Institut, Universitätsklinikum Erlangen, Erlangen</wicri:regionArea><placeName><settlement type="city">Erlangen</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Moyenne-Franconie</region></placeName></affiliation></author><author><name sortKey="Muller, S" sort="Muller, S" uniqKey="Muller S" first="S" last="Müller">S. Müller</name><affiliation wicri:level="1"><nlm:affiliation>MVZ-Zentrum für Histologie, Zytologie und Molekulare Diagnostik, Trier, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>MVZ-Zentrum für Histologie, Zytologie und Molekulare Diagnostik, Trier</wicri:regionArea><wicri:noRegion>Trier</wicri:noRegion><wicri:noRegion>Trier</wicri:noRegion><wicri:noRegion>Trier</wicri:noRegion></affiliation></author><author><name sortKey="Parvizi, J" sort="Parvizi, J" uniqKey="Parvizi J" first="J" last="Parvizi">J. Parvizi</name><affiliation wicri:level="3"><nlm:affiliation>The Rothman Institute at Thomas Jefferson University, Sheridan Building, Philadelphia, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Rothman Institute at Thomas Jefferson University, Sheridan Building, Philadelphia</wicri:regionArea><placeName><settlement type="city">Philadelphie</settlement><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Illgner, U" sort="Illgner, U" uniqKey="Illgner U" first="U" last="Illgner">U. Illgner</name><affiliation wicri:level="1"><nlm:affiliation>St. Josef-Stift Sendenhorst, Klinik für Orthopädie, Unfall- und Handchirurgie, Sendenhorst, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>St. Josef-Stift Sendenhorst, Klinik für Orthopädie, Unfall- und Handchirurgie, Sendenhorst</wicri:regionArea><wicri:noRegion>Sendenhorst</wicri:noRegion><wicri:noRegion>Sendenhorst</wicri:noRegion><wicri:noRegion>Sendenhorst</wicri:noRegion></affiliation></author><author><name sortKey="Gehrke, T" sort="Gehrke, T" uniqKey="Gehrke T" first="T" last="Gehrke">T. Gehrke</name><affiliation wicri:level="3"><nlm:affiliation>Helios Endo-Klinik, Hamburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Helios Endo-Klinik, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author></analytic><series><title level="j">Pathology, research and practice</title><idno type="eISSN">1618-0631</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Arthroplasty, Replacement (adverse effects)</term><term>Arthroplasty, Replacement (instrumentation)</term><term>Biomarkers (analysis)</term><term>Biopsy</term><term>Consensus</term><term>Humans</term><term>Immunohistochemistry</term><term>Joint Prosthesis (adverse effects)</term><term>Joints (chemistry)</term><term>Joints (pathology)</term><term>Joints (surgery)</term><term>Predictive Value of Tests</term><term>Prosthesis Design</term><term>Prosthesis Failure</term><term>Prosthesis-Related Infections (classification)</term><term>Prosthesis-Related Infections (metabolism)</term><term>Prosthesis-Related Infections (pathology)</term><term>Terminology as Topic</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Biomarkers</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Arthroplasty, Replacement</term><term>Joint Prosthesis</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Joints</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Prosthesis-Related Infections</term></keywords><keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Arthroplasty, Replacement</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Prosthesis-Related Infections</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Joints</term><term>Prosthesis-Related Infections</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Joints</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Biopsy</term><term>Consensus</term><term>Humans</term><term>Immunohistochemistry</term><term>Predictive Value of Tests</term><term>Prosthesis Design</term><term>Prosthesis Failure</term><term>Terminology as Topic</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This extended classification of joint implant related pathology is a practical histopathologic classification based on defined morphological criteria covering the complete spectrum of pathohistologic changes in periprosthetic tissues. These changes may occur as a consequence of endoprosthetic replacement of large joints and may lead to a reduction in the prosthesis survival rate. We describe the established consensus classification of the periprosthetic membrane, in which aseptic and septic prosthetic loosening can be subdivided into four histological types, as well as histopathological criteria for additional significant pathologies including endoprosthetic-associated arthrofibrosis, particle-induced immunological, inflammatory and toxic mechanisms (adverse reactions), and bone tissue pathologies. These characteristic tissue alterations and their relationships are summarized in the extended classification. Since particle heterogeneity in periprosthetic tissue is high and particle identification is a necessary part of diagnosis, the identification of different types of particles is described in the histopathological particle algorithm. The morphological qualities of prosthetic material particles and the demarcation between abrasion and non-abrasion endogenous particles are also summarized. This feasible classification which is based on low cost standard tissue processing and examination and on well-defined diagnostic criteria is a solid platform for the histological diagnosis of implant associated pathologies providing a stable and reproducible tool for the surgical pathologist. Since this classification is suitable for standardized histopathological diagnostics, it might also provide a useful data set for joint arthroplasty registers, particularly for registers based on so-called routine data.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Autriche</li><li>Royaume-Uni</li><li>Russie</li><li>Suisse</li><li>États-Unis</li></country><region><li>Basse-Saxe</li><li>Bavière</li><li>Berlin</li><li>Brandebourg</li><li>District de Haute-Bavière</li><li>District de Moyenne-Franconie</li><li>Hambourg</li><li>Pennsylvanie</li><li>Schleswig-Holstein</li><li>Vienne (Autriche)</li><li>État de New York</li></region><settlement><li>Berlin</li><li>Erlangen</li><li>Hambourg</li><li>Kiel</li><li>Munich</li><li>Osnabrück</li><li>Philadelphie</li><li>Potsdam</li><li>Vienne (Autriche)</li></settlement></list><tree><country name="Allemagne"><noRegion><name sortKey="Krenn, V" sort="Krenn, V" uniqKey="Krenn V" first="V" last="Krenn">V. Krenn</name></noRegion><name sortKey="Ascherl, R" sort="Ascherl, R" uniqKey="Ascherl R" first="R" last="Ascherl">R. Ascherl</name><name sortKey="Frommelt, L" sort="Frommelt, L" uniqKey="Frommelt L" first="L" last="Frommelt">L. Frommelt</name><name sortKey="Gehrke, T" sort="Gehrke, T" uniqKey="Gehrke T" first="T" last="Gehrke">T. Gehrke</name><name sortKey="Hassenpflug, G J" sort="Hassenpflug, G J" uniqKey="Hassenpflug G" first="G J" last="Hassenpflug">G J Hassenpflug</name><name sortKey="Illgner, U" sort="Illgner, U" uniqKey="Illgner U" first="U" last="Illgner">U. Illgner</name><name sortKey="Kendoff, D" sort="Kendoff, D" uniqKey="Kendoff D" first="D" last="Kendoff">D. Kendoff</name><name sortKey="Kienapfel, H" sort="Kienapfel, H" uniqKey="Kienapfel H" first="H" last="Kienapfel">H. Kienapfel</name><name sortKey="Kolbel, B" sort="Kolbel, B" uniqKey="Kolbel B" first="B" last="Kölbel">B. Kölbel</name><name sortKey="Kretzer, J P" sort="Kretzer, J P" uniqKey="Kretzer J" first="J P" last="Kretzer">J P Kretzer</name><name sortKey="Krukemeyer, M G" sort="Krukemeyer, M G" uniqKey="Krukemeyer M" first="M G" last="Krukemeyer">M G Krukemeyer</name><name sortKey="Morawietz, L" sort="Morawietz, L" uniqKey="Morawietz L" first="L" last="Morawietz">L. Morawietz</name><name sortKey="Muller, S" sort="Muller, S" uniqKey="Muller S" first="S" last="Müller">S. Müller</name><name sortKey="Ruther, W" sort="Ruther, W" uniqKey="Ruther W" first="W" last="Rüther">W. Rüther</name><name sortKey="Soder, S" sort="Soder, S" uniqKey="Soder S" first="S" last="Söder">S. Söder</name><name sortKey="Thomas, P" sort="Thomas, P" uniqKey="Thomas P" first="P" last="Thomas">P. Thomas</name><name sortKey="Thomsen, M" sort="Thomsen, M" uniqKey="Thomsen M" first="M" last="Thomsen">M. Thomsen</name><name sortKey="Tiemann, A" sort="Tiemann, A" uniqKey="Tiemann A" first="A" last="Tiemann">A. Tiemann</name><name sortKey="Trampuz, A" sort="Trampuz, A" uniqKey="Trampuz A" first="A" last="Trampuz">A. Trampuz</name><name sortKey="Zustin, J" sort="Zustin, J" uniqKey="Zustin J" first="J" last="Zustin">J. Zustin</name></country><country name="États-Unis"><region name="État de New York"><name sortKey="Perino, G" sort="Perino, G" uniqKey="Perino G" first="G" last="Perino">G. Perino</name></region><name sortKey="Boettner, F" sort="Boettner, F" uniqKey="Boettner F" first="F" last="Boettner">F. Boettner</name><name sortKey="Parvizi, J" sort="Parvizi, J" uniqKey="Parvizi J" first="J" last="Parvizi">J. Parvizi</name></country><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Huber, M" sort="Huber, M" uniqKey="Huber M" first="M" last="Huber">M. Huber</name></region></country><country name="Suisse"><noRegion><name sortKey="Baumhoer, D" sort="Baumhoer, D" uniqKey="Baumhoer D" first="D" last="Baumhoer">D. Baumhoer</name></noRegion></country><country name="Royaume-Uni"><noRegion><name sortKey="Natu, S" sort="Natu, S" uniqKey="Natu S" first="S" last="Natu">S. Natu</name></noRegion></country><country name="Russie"><noRegion><name sortKey="Tichilow, R" sort="Tichilow, R" uniqKey="Tichilow R" first="R" last="Tichilow">R. Tichilow</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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